Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …

Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …

The prime editors (PEs) have shown great promise for precise genome modification.
However, their suboptimal efficiencies present a significant technical challenge. Here, by …

Predicting RNA three-dimensional structures from sequence could accelerate
understanding of the growing number of RNA molecules being discovered across biology …

Glioblastoma is a highly lethal brain cancer that frequently recurs in proximity to the original
resection cavity. We explored the use of oncolytic virus therapy against glioblastoma with …

Zika virus (ZIKV) infection of pregnant women can cause a wide range of congenital
abnormalities, including microcephaly, in the infant, a condition now collectively known as …

The structural flexibility of RNA underlies fundamental biological processes, but there are no
methods for exploring the multiple conformations adopted by RNAs in vivo. We developed …

Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense
RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped …

Virion assembly is an important step in the life cycle of all viruses. For viruses of the
Flavivirus genus, a group of enveloped positive-sense RNA viruses, the assembly step …