Bad phosphorylation as a target of inhibition in oncology

V Pandey, T Zhu, L Ma, PE Lobie - Cancer letters, 2018 - Elsevier
Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses
important regulatory function in apoptosis. BAD has also been shown to possess many non …

[HTML][HTML] Apoptosis and genes involved in oral cancer-a comprehensive review

R Dwivedi, R Pandey, S Chandra, D Mehrotra - Oncology reviews, 2020 - ncbi.nlm.nih.gov
Oral cancers needs relentless research due to high mortality and morbidity associated with
it. Despite of the comparable ease in accessibility to these sites, more than 2/3 rd cases are …

GPER‐induced signaling is essential for the survival of breast cancer stem cells

YT Chan, ACY Lai, RJ Lin, YH Wang… - … journal of cancer, 2020 - Wiley Online Library
G protein‐coupled estrogen receptor‐1 (GPER), a member of the G protein‐coupled
receptor (GPCR) superfamily, mediates estrogen‐induced proliferation of normal and …

Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis

QM Zhou, Y Sun, YY Lu, H Zhang, QL Chen… - Cancer Cell …, 2017 - Springer
Background Curcumin, a natural compound derived from the turmeric rhizome Curcuma
longa Linn, has anticancer and chemoresistance reduction biological activities. We …

Apoptosis induced by (−)-epicatechin in human breast cancer cells is mediated by reactive oxygen species

F Pereyra-Vergara, IM Olivares-Corichi, AG Perez-Ruiz… - Molecules, 2020 - mdpi.com
(−)-Epicatechin is a phenolic compound with antioxidant activity that is present in natural
food and drinks, such as cocoa and red wine. Evidence suggests that (−)-epicatechin …

The protective effect of grape seed procyanidin extract against cadmium-induced renal oxidative damage in mice

Q Chen, R Zhang, W Li, Y Niu, H Guo, X Liu… - Environmental …, 2013 - Elsevier
As an important environmental pollutant, cadmium (Cd) can lead to serious renal damage.
Grape seed procyanidins extract (GSPE), a biological active component of grape seed, has …

Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways …

T Zhang, GY Liu, JL Cao, YN Li, H Xue… - Drug Development …, 2022 - Wiley Online Library
Peimine (PM), a natural product extracted from Fritillaria, has anti‐inflammatory, drug
resistance reversal, and other pharmacological effects. The purpose of this study was to …

[HTML][HTML] The function role of miR-181a in chemosensitivity to adriamycin by targeting Bcl-2 in low-invasive breast cancer cells

Y Zhu, J Wu, S Li, R Ma, H Cao, M Ji, C Jing… - Cellular physiology and …, 2013 - karger.com
Objectives: miR-181a is involved in immunity, metabolism, tumor suppression or
carcinogenesis reported by many other studies. However, its role in the development of …

Androgens Modulate Bcl-2 Agonist of Cell Death (BAD) Expression and Function in Breast Cancer Cells

C Morelli, C Chiodo, MC Nocito, A Cormace… - International Journal of …, 2023 - mdpi.com
Androgen receptor (AR) expression in estrogen receptor-positive (ER+) breast cancer (BC)
correlates with lower tumor grade and a better clinical outcome. Additionally, in normal …

Morin, a flavonoid from moraceae, induces apoptosis by induction of BAD protein in human leukemic cells

C Park, WS Lee, SI Go, A Nagappan, MH Han… - International journal of …, 2014 - mdpi.com
Evidence suggests that phytochemicals can safely modulate cancer cell biology and induce
apoptosis. Here, we investigated the anti-cancer activity of morin, a flavone originally …