Buruli ulcer: a review of the current knowledge

RR Yotsu, K Suzuki, RE Simmonds, R Bedimo… - … tropical medicine reports, 2018 - Springer
Abstract Purpose of the Review Buruli ulcer (BU) is a necrotizing and disabling cutaneous
disease caused by Mycobacterium ulcerans, one of the skin-related neglected tropical …

Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection With Mycobacterium ulcerans

K Röltgen, G Pluschke - Frontiers in microbiology, 2020 - frontiersin.org
Buruli ulcer (BU) is a neglected, tropical infectious disease of the skin and the subcutaneous
tissue caused by Mycobacterium ulcerans. This pathogen has emerged as a new species …

Type-I interferons promote innate immune tolerance in macrophages exposed to Mycobacterium ulcerans vesicles

Q Bernard, M Goumeidane, E Chaumond… - PLoS …, 2023 - journals.plos.org
Buruli ulcer is a chronic infectious disease caused by Mycobacterium ulcerans. The
pathogen persistence in host skin is associated with the development of ulcerative and …

Spontaneous healing of Mycobacterium ulcerans disease in Australian patients

DP O'Brien, A Murrie, P Meggyesy… - PLoS neglected …, 2019 - journals.plos.org
Background Mycobacterium ulcerans causes necrotising infections of skin and soft tissue
mediated by the polyketide exotoxin mycolactone that causes cell apoptosis and immune …

Vaccine-specific immune responses against Mycobacterium ulcerans infection in a low-dose murine challenge model

KM Mangas, AH Buultjens, JL Porter… - Infection and …, 2020 - Am Soc Microbiol
The neglected tropical disease Buruli ulcer (BU) is an infection of subcutaneous tissue with
Mycobacterium ulcerans. There is no effective vaccine. Here, we assessed an experimental …

Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection

M Foulon, A Pouchin, J Manry, F Khater… - Science …, 2020 - science.org
Buruli ulcer, a neglected tropical infectious disease, is caused by Mycobacterium ulcerans.
Without treatment, its lesions can progress to chronic skin ulcers, but spontaneous healing is …

Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone

M Robbe-Saule, M Foulon, I Poncin, L Esnault, H Varet… - Virulence, 2021 - Taylor & Francis
Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and
the third most common mycobacterial disease worldwide. Without early treatment, M …

An Optimized Method for Extracting Bacterial RNA from Mouse Skin Tissue Colonized by Mycobacterium ulcerans

M Robbe-Saule, J Babonneau, O Sismeiro… - Frontiers in …, 2017 - frontiersin.org
Bacterial transcriptome analyses during host colonization are essential to decipher the
complexity of the relationship between the bacterium and its host. RNA sequencing (RNA …

Mycolactone as analgesic: subcutaneous bioavailability parameters

J Babonneau, D Bréard, ML Reynaert… - Frontiers in …, 2019 - frontiersin.org
Mycobacterium ulcerans is the bacillus responsible for Buruli ulcer, an infectious disease
and the third most important mycobacterial disease worldwide, after tuberculosis and …

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against …

KM Mangas, NJ Tobias, E Marion, J Babonneau… - PeerJ, 2020 - peerj.com
Background Mycobacterium ulcerans is the causative agent of a debilitating skin and soft
tissue infection known as Buruli ulcer (BU). There is no vaccine against BU. The purpose of …