Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

ZM Manjaly, NA Harrison, HD Critchley… - Journal of Neurology …, 2019 - jnnp.bmj.com
Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact
on patients' quality of life. Currently, treatment proceeds by trial and error with limited …

The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee

R Chen, D Cros, A Curra, V Di Lazzaro… - Clinical …, 2008 - Elsevier
The review focuses on the clinical diagnostic utility of transcranial magnetic stimulation
(TMS). The central motor conduction time (CMCT) is a sensitive method to detect …

Promoting remyelination in multiple sclerosis

N Cunniffe, A Coles - Journal of neurology, 2021 - Springer
The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or
reverse progression. One of the most tractable strategies to achieve this is to therapeutically …

Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study

A Genchi, E Brambilla, F Sangalli, M Radaelli… - Nature medicine, 2023 - nature.com
Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS),
combining neuroprotection and immunomodulation, represent an unmet need. Neural …

Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology …

G Morris, M Maes - BMC medicine, 2013 - Springer
Background 'Encephalomyelitis disseminata'(multiple sclerosis) and myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS) are both classified as diseases of the …

[图书][B] Spinal cord medicine

S Kirshblum, VW Lin - 2018 - books.google.com
In this comprehensive, clinically directed, reference for the diagnosis and treatment of
persons with spinal cord injury and related disorders, editors of the two leading texts on …

Treatment of patients with multiple sclerosis transitioning between relapsing and progressive disease

NG Dimitriou, SG Meuth, EH Martinez-Lapiscina… - CNS drugs, 2023 - Springer
Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative
disease of the central nervous system with a wide variety of clinical phenotypes. In spite of …

Machine learning analysis of motor evoked potential time series to predict disability progression in multiple sclerosis

J Yperman, T Becker, D Valkenborg, V Popescu… - BMC neurology, 2020 - Springer
Abstract Background Evoked potentials (EPs) are a measure of the conductivity of the
central nervous system. They are used to monitor disease progression of multiple sclerosis …

A new role for evoked potentials in MS? Repurposing evoked potentials as biomarkers for clinical trials in MS

M Hardmeier, L Leocani, P Fuhr - Multiple Sclerosis Journal, 2017 - journals.sagepub.com
Evoked potentials (EP) characterize signal conduction in selected tracts of the central
nervous system in a quantifiable way. Since alteration of signal conduction is the main …

FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis

B Balatoni, MK Storch, EM Swoboda, V Schönborn… - Brain research …, 2007 - Elsevier
FTY720 (fingolimod) is an oral sphingosine 1-phosphate (S1P) receptor modulator under
development for the treatment of multiple sclerosis (MS). To elucidate its effects in the central …