The leucine-responsive regulatory proteins/feast-famine regulatory proteins: an ancient and complex class of transcriptional regulators in bacteria and archaea
CA Ziegler, PL Freddolino - Critical reviews in biochemistry and …, 2021 - Taylor & Francis
Since the discovery of the Escherichia coli leucine-responsive regulatory protein (Lrp)
almost 50 years ago, hundreds of Lrp homologs have been discovered, occurring in 45% of …
almost 50 years ago, hundreds of Lrp homologs have been discovered, occurring in 45% of …
Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors
W Deng, H Wang, J Xie - Journal of cellular biochemistry, 2011 - Wiley Online Library
Lrp/AsnC (leucine‐responsive regulatory protein/asparagine synthase C products) family
transcriptional regulators, widespread among bacteria and archaea, is also known as …
transcriptional regulators, widespread among bacteria and archaea, is also known as …
Mycobacterium tuberculosis Rv2324 is a multifunctional feast/famine regulatory protein involved in growth, DNA replication and damage control
Feast/famine regulatory proteins (FFRPs) are multifunctional regulators. We show that Mtb
Rv2324 is important for growth, survival, and countering DNA damage in Mycobacterium …
Rv2324 is important for growth, survival, and countering DNA damage in Mycobacterium …
Escherichia coli Leucine-Responsive Regulatory Protein Bridges DNA In Vivo and Tunably Dissociates in the Presence of Exogenous Leucine
CA Ziegler, PL Freddolino - MBio, 2023 - Am Soc Microbiol
Feast-famine response proteins are a widely conserved class of global regulators in
prokaryotes, the most highly studied of which is the Escherichia coli leucine-responsive …
prokaryotes, the most highly studied of which is the Escherichia coli leucine-responsive …
Alanine dehydrogenases in mycobacteria
JA Jeong, JI Oh - Journal of Microbiology, 2019 - Springer
Abstract Since NAD (H)-dependent L-alanine dehydrogenase (EC 1.1. 4.1; Ald) was
identified as one of the major antigens present in culture filtrates of Mycobacterium …
identified as one of the major antigens present in culture filtrates of Mycobacterium …
Regulation of the CRISPR-associated genes by Rv2837c (CnpB) via an orn-like activity in tuberculosis complex mycobacteria
Y Zhang, J Yang, G Bai - Journal of Bacteriology, 2018 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-
associated proteins (Cas) provide bacteria and archaea with adaptive immunity to specific …
associated proteins (Cas) provide bacteria and archaea with adaptive immunity to specific …
Structural biology of Mycobacterium tuberculosis proteins: the Indian efforts
Among the many different objectives of large scale structural genomics projects are
expanding the protein fold space, enhancing understanding of a model or disease-related …
expanding the protein fold space, enhancing understanding of a model or disease-related …
Crystal structure of Mycobacterium tuberculosis H37Rv AldR (Rv2779c), a regulator of the ald gene: DNA binding and identification of small molecule inhibitors
Here we report the crystal structure of M. tuberculosis AldR (Rv2779c) showing that the N-
terminal DNA-binding domains are swapped, forming a dimer, and four dimers are …
terminal DNA-binding domains are swapped, forming a dimer, and four dimers are …
BarR, an Lrp‐type transcription factor in Sulfolobus acidocaldarius, regulates an aminotransferase gene in a β‐alanine responsive manner
H Liu, A Orell, D Maes, M Van Wolferen… - Molecular …, 2014 - Wiley Online Library
In archaea, nothing is known about the β‐alanine degradation pathway or its regulation. In
this work, we identify and characterize BarR, a novel Lrp‐like transcription factor and the first …
this work, we identify and characterize BarR, a novel Lrp‐like transcription factor and the first …
Regulation Mechanism of the ald Gene Encoding Alanine Dehydrogenase in Mycobacterium smegmatis and Mycobacterium tuberculosis by the Lrp/AsnC Family …
JA Jeong, J Hyun, JI Oh - Journal of bacteriology, 2015 - Am Soc Microbiol
In the presence of alanine, AldR, which belongs to the Lrp/AsnC family of transcriptional
regulators and regulates ald encoding alanine dehydrogenase in Mycobacterium …
regulators and regulates ald encoding alanine dehydrogenase in Mycobacterium …