The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
Individual SCN neurons in dispersed culture can generate independent circadian …

A wide variety of biological experiments rely on the ability to express an exogenous gene in
a transgenic animal at a defined level and in a spatially and temporally controlled pattern …

Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we
show, using optogenetic manipulation and video recording, that a subset of dorsal clock …

The organization of biological activities into daily cycles is universal in organisms as diverse
as cyanobacteria, fungi, algae, plants, flies, birds and man. Comparisons of circadian clocks …

Gut microbiome profoundly affects many aspects of host physiology and behaviors. Here we
report that gut microbiome modulates aggressive behaviors in Drosophila. We found that …

The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a
network structure composed of multiple types of neurons. Here, we report that mice with a …

In Drosophila, a 'clock'situated in the brain controls circadian rhythms of locomotor activity.
This clock relies on several groups of neurons that express the Period (PER) protein …

Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …

An intrinsic clock enables an organism to anticipate environmental changes and use energy
sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock …