Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is
characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in …

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …

Xanthones are a class of oxygen containing heterocyclic compounds with a broad range of
biological activities, and they have prominent significance in the field of medicinal chemistry …

Background Alzheimer's disease (AD) is the most common cause of dementia characterized
by progressive cognitive impairment in the elderly people. The most dramatic abnormalities …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …

The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget
strategies to combat causes and symptoms. We therefore designed, synthesized, and tested …

One of the characteristics of Alzheimer's disease (AD) that hinders the discovery of effective
disease-modifying therapies is the multifactorial nature of its etiopathology. To circumvent …

The multifactorial nature of Alzheimer's disease calls for the development of multitarget
agents addressing key pathogenic processes. To this end, by following a docking-assisted …

We report a chemo/starvation/chemodynamic trimodal combination therapy to combat
multidrug-resistant (MDR) tumors by developing a ferrocene-containing nanovesicle (FcNV) …