Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Melanogenesis is a process to synthesize melanin, which is a primary responsible for the
pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and …

Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

Abstract A series of new 1, 2, 3-triazole linked coumarinopyrazole conjugates 4a-e and 5a-e
have been synthesized via the Copper (I)-catalysed Alkyne-Azide Cycloaddition (CuAAC) …

Considering highly valuable biological and pharmaceutical properties of coumarins, the
synthesis of these heterocycles has been considered for many organic and pharmaceutical …

Benzothiazepines are pharmacologically active compounds, frequently utilized as a
precursor for acquiring versatile molecules with several bioactivities including anti …

Lawesson's reagent (LR) is a well-known classic example of a compound with unique
construction and unusual chemical behavior, with a wide range of applications in synthetic …

Tyrosinase is a bifunctional polyphenol oxidase (PPO), catalyzing two oxidative reactions:
monophenols to o-quinones (monophenolase activity) and o-diphenols to oquinones …

OBJECTIVE: The growing bacterial resistance towards classical antibiotics demands the
development of novel approaches for the effective treatment of potentially fatal bacterial …

The present method provides a wide scope and quick access to dihydropyrido [2, 3-d: 6, 5-
d′] dipyrimidinetetraone and pyrimido [4, 5-d] pyrimidine derivatives in good to excellent …