Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

The unique properties of chitosan make it a useful choice for various nanoparticulate drug
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …

Whereas some rare lipids contribute to the identity of cell organelles, we focus on the
abundant lipids that form the matrix of organelle membranes. Observations using bioprobes …

Lipids stimulated and favored the evolution of the brain. Adult human brain contains a large
amount of lipids, and the largest diversity of lipid classes and lipid molecular species …

Neutrophils are the most abundant circulating leukocyte and are crucial to the initial innate
immune response to infection. One of their key pathogen‐eliminating mechanisms is …

Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling
molecules in various physiological and pathological processes. A myriad of studies have …

Computationally driven engineering of proteins aims to allow them to withstand an extended
range of conditions and to mediate modified or novel functions. Therefore, it is crucial to the …

The superoxide-generating NADPH oxidase of phagocytes consists of the membrane-
associated cytochrome b 558 (a heterodimer of Nox2 and p22 phox) and 4 cytosolic …

The Gram-negative bacterium Salmonella enterica has developed an array of sophisticated
tools to manipulate the host cell and establish an intracellular niche, for successful …