Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …

The indole nucleus is an important element of many natural and synthetic molecules with
significant biological activity. This review covers some of the relevant and recent …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Arylthioindoles (ATIs) that possess a 3-methoxyphenylthio or a 3, 5-dimethoxyphenylthio
moiety at position 2 of the indole ring were effective tubulin assembly inhibitors, but weak …

Microtubules are the basic components of cell structure, which take part in a wide number of
pivotal cellular functions. Drugs that are able to modulate the microtubule assembly either by …

Isatin (1H-indole-2, 3-dione) and its derivatives demonstrate a diverse array of biological
and pharmacological activities including anticonvulsant, antibacterial, antifungal, antiviral …

A norbornene-mediated palladium-catalyzed tandem alkylation/C− H functionalization
sequence is described, in which an alkyl− aryl bond and a heteroaryl− aryl bond are formed …

Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and
of the growth of MCF-7 human breast carcinoma cells. Methyl 3-[(3, 4, 5-trimethoxyphenyl) …