One of the key differentiators between biological and artificial systems is the dynamic
plasticity of living tissues, enabling adaptation to different environmental conditions, tasks, or …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

The rich variety of biological forms and behaviours results from one evolutionary history on
Earth, via frozen accidents and selection in specific environments. This ubiquitous baggage …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Recent technological breakthroughs in our ability to derive and differentiate induced
pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all …

Comparative studies of mortality in the wild are necessary to understand the evolution of
aging; yet, ectothermic tetrapods are underrepresented in this comparative landscape …

There are 64,000 living species of vertebrates on our planet and all of them have a heart.
Comparative analyses devoted to understanding the regenerative potential of the …

The liver harbors a distinct capacity for endogenous regeneration; however, liver
regeneration is often impaired in disease and therefore insufficient to compensate for the …

Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a
functional tail. Understanding the molecular basis of this process would advance …

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …