Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

A significant pathological signature of Alzheimer's disease (AD) is the deposition of amyloid-
β (Aβ) plaques in the brain and the synaptic dysfunction and neurodegeneration associated …

A combination of tacrine and tryptophan led to the development of a new family of
heterodimers as multi-target agents with potential to treat Alzheimer's disease. Based on the …

Multi-target drug discovery is one of the most followed approaches in the active central
nervous system (CNS) therapeutic area, especially in the search for new drugs against …

Abstract Myricetin (3, 5, 7, 3′, 4′, 5′-hexahydroxyflavone) is one of the natural flavonols
from fruit, vegetable, tea, and medicinal plants. A great deal of attention has been paid to this …

Dye-binding assays, such as those utilizing Congo red and thioflavin T, are among the most
widely used tools to probe the aggregation of amyloidogenic biomolecules and for the …

The formation of amyloid β (Aβ) fibrils is crucial in initiating the cascade of pathological
events that culminates in Alzheimer's disease. In this study, we investigated the mechanism …

The aggregation of Aβ42 is a hallmark of Alzheimer's disease. It is still not known what the
biochemical changes are inside a cell which will eventually lead to Aβ42 aggregation …

The mortality rates of age-related diseases (ARDs) increase exponentially with age.
Processes described by the exponential growth function typically involve a branching chain …