Warfarin is a widely used anticoagulant with a narrow therapeutic index and large
interpatient variability in the dose required to achieve target anticoagulation. Common …

Individual variability in drug efficacy and drug safety is a major challenge in current clinical
practice, drug development, and drug regulation. For more than 5 decades, studies of …

We report the first genome-wide association study (GWAS) whose sample size (1,053
Swedish subjects) is sufficiently powered to detect genome-wide significance (p< 1.5× 10 …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

Motivation: Widespread availability of low-cost, full genome sequencing will introduce new
challenges for bioinformatics. Results: This review outlines recent developments in …

Coagulation involves the regulated sequence of proteolytic activation of a series of
zymogens to achieve appropriate and timely haemostasis in an injured vessel, in an …

The advent of high‐throughput technologies has proven valuable in the assessment of
genetic differences and their effects on drug activation, metabolism, disposition, and …

Genotype‐guided warfarin dosing algorithms are a rational approach to optimize warfarin
dosing and potentially reduce adverse drug events. Diverse populations, such as African …

Background: Tamoxifen is a standard endocrine therapy for the prevention and treatment of
steroid hormone receptor–positive breast cancer. Content: Tamoxifen requires enzymatic …

Aims: CYP4F2* 3 (p. V433M) has been associated with higher warfarin dose requirements;
however, its frequency, like other CYP2C9 and VKORC1 variants, has not been …