Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that
arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic …

This manuscript is the result of the North American Neuroendocrine Tumor Society
consensus conference on the medical management and surveillance of metastatic and …

The integration of genomic testing into clinical care enables the use of individualized
approaches to the management of rare diseases. We describe the use of belzutifan, a potent …

JAK2 unmutated or non-polycythemia vera (PV) erythrocytosis encompasses both hereditary
and acquired conditions. A systematic diagnostic approach begins with documentation of …

Pheochromocytomas (PHEOs) are rare neuroendocrine tumors that arise from the
chromaffin cells of the adrenal glands. Paragangliomas (PGLs), the extra-adrenal …

This review focuses on discussing the main modifications of the recently published 2017
WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent …

ABSTRACT Objective: Overall about 10 to 20% of pheochromocytomas/paragangliomas
(PHEOs/PGLs) are metastatic, with higher metastatic potential observed in succinate …