Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules
As a non-invasive route, intranasal administration offers patient comfort and compliance
which are hurdled in parenteral drug therapy. In addition, the current recognition that the …
which are hurdled in parenteral drug therapy. In addition, the current recognition that the …
Recent update on pharmacokinetics and drug metabolism in CNS-based drug discovery
Despite significant advancements in CNS research, CNS illnesses are the most important
and serious cause of mental disability worldwide. These facts show a tremendous unmet …
and serious cause of mental disability worldwide. These facts show a tremendous unmet …
Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: preparation, characterization, and in vivo evaluation
A Alshweiat, II Csóka, F Tömösi, T Janáky… - International journal of …, 2020 - Elsevier
The unique requirements of poorly water-soluble drug delivery have driven a great deal of
research into new formulations and routes of administration. This study investigates the use …
research into new formulations and routes of administration. This study investigates the use …
Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery
Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain
diseases. However, a large amount of free curcumin needs to be administered to achieve an …
diseases. However, a large amount of free curcumin needs to be administered to achieve an …
Intranasal drug delivery: A non-invasive approach for the better delivery of neurotherapeutics
Background: The convoluted pathophysiology of brain disorders along with penetration
issue of drugs to brain represents major hurdle that requires some novel therapies. The …
issue of drugs to brain represents major hurdle that requires some novel therapies. The …
Preparation and in vitro/in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application
Flurbiprofen (FB) is an analgesic and anti-inflammatory drug, but its low water solubility
(BCS Class II) limits its dermal bioavailability. The aim of this study is to develop a FB …
(BCS Class II) limits its dermal bioavailability. The aim of this study is to develop a FB …
In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration
Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first
pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes …
pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes …
Drug-metabolizing enzymes and efflux transporters in nasal epithelium: influence on the bioavailability of intranasally administered drugs
Background: The interest in administering drugs by intranasal route is currently increasing,
particularly because it has shown to ensure drug therapeutic action by a rapid systemic …
particularly because it has shown to ensure drug therapeutic action by a rapid systemic …
Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms
N Changsan, S Sawatdee, R Suedee… - International Journal of …, 2023 - Elsevier
Cannabidiol (CBD) has a number of biological effects by acting on the cannabinoid
receptors CB 1 and CB 2. CBD may be involved in anti-inflammatory processes via CB 1 …
receptors CB 1 and CB 2. CBD may be involved in anti-inflammatory processes via CB 1 …
Nanomedicine for intranasal delivery to improve brain uptake
Intranasal drug delivery system provides distinct advantage over conventional drug delivery
system for a drug that is pharmacokenetically or biologically unstable. Major concern for the …
system for a drug that is pharmacokenetically or biologically unstable. Major concern for the …