Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …

Enhancers are noncoding regulatory elements that instruct spatial and temporal specificity of
gene transcription in response to a variety of intrinsic and extrinsic signals during …

Differential gene transcription enables development and homeostasis in all animals and is
regulated by two major classes of distal cis-regulatory DNA elements (CREs): enhancers …

Gene expression is controlled by the precise activation and repression of transcription.
Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors …

Genomic enhancers are key transcriptional regulators which, upon the binding of sequence-
specific transcription factors, activate their cognate target promoters. Although enhancers …

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …

SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …

Biophysical constraints limit the specificity with which transcription factors (TFs) can target
regulatory DNA. While individual nontarget binding events may be low affinity, the sheer …

Chromatin modifiers and transcriptional cofactors (collectively referred to as CFs) work with
DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular …