Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic
demands to power rapid division. For many years considered a passive component or" …

Pluripotent stem cells of the mammalian epiblast and their cultured counterparts—embryonic
stem cells (ESCs) and epiblast stem cells (EpiSCs)—have the capacity to differentiate in all …

The highly widespread and infiltrative nature of glioblastoma multiforme (GBM) makes
complete surgical resection hard, causing high recurrence rate and poor patients' prognosis …

The pluripotency of stem cells determines their developmental potential. While the
pluripotency states of pluripotent stem cells are variable and interconvertible, the …

Domestic cats suffer from a range of inherited genetic diseases, many of which display
similarities with equivalent human conditions. Developing cellular models for these inherited …

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) requires activation
of the pluripotency network and resetting of the epigenome by erasing the epigenetic …

Although potent direct-acting antiviral drugs for the treatment of chronic hepatitis C virus
(HCV) infection are licensed, there are more than 70 million individuals suffering from …

Xenopus egg extract is a powerful material to modify cultured cells fate and to induce
cellular reprogramming in mammals. In this study, the response of goldfish fin cells to in vitro …

Hepatitis C virus (HCV) is highly dependent on cellular factors for viral propagation. Using
high-throughput next-generation sequencing, we analyzed the host transcriptomic changes …

Highlights•Metabolism regulates stem cell fate by altering epigenetic markers.•Metabolite
signatures can be used to characterize differences between cell types.•Metabolomics can be …