Mismatch repair proficient (MMRp) tumors of colorectal origin are one of the prevalent yet
unpredictable clinical challenges. Despite earnest efforts, optimal treatment modalities have …

Organoids are three-dimensional (3D) cultures, normally derived from stem cells, that
replicate the complex structure and function of human tissues. They offer a physiologically …

Patient-derived tumor organoids have been leveraged for disease modeling and preclinical
studies but rarely applied in real time to aid with interpretation of patient treatment responses …

Background Tumor cells have the ability to invade and form small clusters that protrude into
adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it …

Chemotherapy drugs like doxorubicin (Dox) are widely used in middle-income countries
around the world to treat various types of cancers, including breast cancer. Although they …

Breast cancer adaptability to the drug environment reduces the chemotherapeutic response
and facilitates acquired drug resistance. Cancer-specific therapeutics can be more effective …

共激活蛋白相关的精氨酸甲基转移酶1 (coactivator-associated arginine methyltransferase 1,
CARM1) 是蛋白质精氨酸甲基转移酶(protein arginine methyltransferase, PRMT) 家族的成员 …

Background Primary luminal breast cancer cells lose their identity rapidly in standard tissue
culture, which is problematic for testing hormone interventions and molecular pathways …

The concept of personalised medicine in cancer therapy is becoming increasingly important.
There already exist drugs administered specifically for patients with tumours presenting well …

Chemotherapy remains the mainstay in most high-risk breast cancer (BC) settings, with
several equivalent options of treatment. However, the efficacy of each treatment varies …