Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Inflammation contributes to many of the characteristics of plaques implicated in the
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and
adaptive immune responses. Inflammation controls the development and the destabilization …

It is well recognized that macrophages in many contexts in vitro and in vivo display a
spectrum of inflammatory features and functional properties. A convenient system to group …

A hallmark of infection with the gram‐negative pathogen Porphyromonas gingivalis is the
induction of a chronic inflammatory response. P. gingivalis induces a local chronic …

Through fragment-based drug design focused on engaging the active site of IRAK4 and
leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit …

Atherosclerosis is a chronic disease characterised by lipid retention and inflammation in the
arterial intima. Innate immune mechanisms are central to atherogenesis, involving activation …