The human gastrointestinal tract is inhabited by the largest microbial community within the
human body consisting of trillions of microbes called gut microbiota. The normal flora is the …

The gut and mitochondria have emerged as two important hubs at the cutting edge of
research across a diverse array of medical conditions, including most psychiatric conditions …

Obesity is a highly prevalent public health concern, attributed to multifactorial causes and
limited in treatment options. Several comorbidities are closely associated with obesity such …

Recent research demonstrates a reciprocal relationship between gut microbiota-derived
metabolites and the host in controlling the energy homeostasis in mammals. On the one …

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease. Sophora flavescens (S.
flavescens), also named Kushen, is a famous Chinese herbal medicine that has been used …

OBJECTIVE To determine the potential use of baseline circulating succinate to predict type 2
diabetes remission after bariatric surgery. RESEARCH DESIGN AND METHODS Forty-five …

Metabolomics emerged as an important tool to gain insights on how the body responds to
therapeutic interventions. Bariatric surgery is the most effective treatment for severe obesity …

Obesity and type 2 diabetes (T2D) lead to defects in intestinal hormones secretion,
abnormalities in the composition of bile acids (BAs), increased systemic and adipose tissue …

OBJECTIVE Type 2 diabetes develops for many years before diagnosis. We aimed to reveal
early metabolic features characterizing liability to adult disease by examining genetic liability …

Cardiometabolic risk is increasing in prevalence across the life span with disproportionate
ramifications for youth at socioeconomic disadvantage. Established risk factors and …