Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals
A Ivanova, P Atakpa-Adaji, S Rao, M Marti-Solano… - Molecular Cell, 2024 - cell.com
The spatial organization of inositol 1, 4, 5-trisphosphate (IP 3)-evoked Ca 2+ signals
underlies their versatility. Low stimulus intensities evoke Ca 2+ puffs, localized Ca 2+ …
underlies their versatility. Low stimulus intensities evoke Ca 2+ puffs, localized Ca 2+ …
The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites
HA Cohen, E Zomot, T Nataniel, R Militsin, R Palty - Cell Reports, 2023 - cell.com
Depletion of Ca 2+ from the endoplasmic reticulum (ER) causes the ER Ca 2+ sensor STIM1
to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM …
to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM …
[HTML][HTML] Phosphatidylinositol 4, 5-bisphosphate and calcium at ER-PM junctions—Complex interplay of simple messengers
A Ivanova, P Atakpa-Adaji - Biochimica et Biophysica Acta (BBA)-Molecular …, 2023 - Elsevier
Endoplasmic reticulum-plasma membrane contact sites (ER-PM MCS) are a specialised
domain involved in the control of Ca 2+ dynamics and various Ca 2+-dependent cellular …
domain involved in the control of Ca 2+ dynamics and various Ca 2+-dependent cellular …
PtdSer as a signaling lipid determined by privileged localization of ORP5 and ORP8 at ER/PM junctional foci to determine PM and ER PtdSer/PI (4) P ratio and cell …
WY Chung, M Ahuja, BA McNally… - Proceedings of the …, 2023 - National Acad Sciences
The membrane contact site ER/PM junctions are hubs for signaling pathways, including
Ca2+ signaling. Phosphatidylserine (PtdSer) mediates various physiological functions; …
Ca2+ signaling. Phosphatidylserine (PtdSer) mediates various physiological functions; …
The Tether Function of the Anoctamins
WY Lin, W Young, S Muallem - Cell Calcium, 2024 - Elsevier
The core functions of the anoctamins are Cl− channel activity and phosphatidylserine (and
perhaps other lipids) scrambling. These functions have been extensively studied in various …
perhaps other lipids) scrambling. These functions have been extensively studied in various …
Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition
YJ Kim, JG Pemberton, A Eisenreichova… - The EMBO …, 2024 - embopress.org
Phosphatidylinositol (PI) is the precursor lipid for the minor phosphoinositides (PPIns), which
are critical for multiple functions in all eukaryotic cells. It is poorly understood how …
are critical for multiple functions in all eukaryotic cells. It is poorly understood how …
Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
J Shen, F Li, X Han, D Fu, Y Xu, C Zhu, Z Liang… - Cell Communication and …, 2024 - Springer
Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its
exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly …
exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly …
[HTML][HTML] A Novel Interaction between Chemokine and Phosphoinositide Signaling in Metastatic Prostate Cancer
C Radoiu, B Govindarajan, M Wang… - Medical research …, 2023 - ncbi.nlm.nih.gov
Prostate cancer commonly metastasizes to bone due to its favorable microenvironment for
cell growth and survival. Currently, the standard of care for metastatic prostate cancer is …
cell growth and survival. Currently, the standard of care for metastatic prostate cancer is …
A better brain? Alternative spliced STIM2 in hominoids arises with synapse formation and creates a gain-of-function variant
V Poth, HT Trang Do, K Förderer, T Tschernig… - bioRxiv, 2023 - biorxiv.org
Balanced Ca2+ homeostasis is essential for cellular functions. STIM2 mediated Store-
Operated Ca2+ Entry (SOCE) regulates cytosolic and ER Ca2+ concentrations, stabilizes …
Operated Ca2+ Entry (SOCE) regulates cytosolic and ER Ca2+ concentrations, stabilizes …