The challenge of de‐labeling penicillin allergy

CA Stone Jr, J Trubiano, DT Coleman, CRF Rukasin… - Allergy, 2020 - Wiley Online Library
Abstract Background Even though 8%‐25% of most populations studied globally are labeled
as penicillin allergic, most diagnoses of penicillin allergy are made in childhood and relate …

[HTML][HTML] Comparative epidemiology of suspected perioperative hypersensitivity reactions

PM Mertes, DG Ebo, T Garcez, M Rose… - British journal of …, 2019 - Elsevier
Suspected perioperative hypersensitivity reactions are rare but contribute significantly to the
morbidity and mortality of surgical procedures. Recent publications have highlighted the …

Development and validation of a penicillin allergy clinical decision rule

JA Trubiano, S Vogrin, KYL Chua, J Bourke… - JAMA internal …, 2020 - jamanetwork.com
Importance Penicillin allergy is a significant public health issue for patients, antimicrobial
stewardship programs, and health services. Validated clinical decision rules are urgently …

[HTML][HTML] Sexually transmitted infections treatment guidelines, 2021

KA Workowski - MMWR. Recommendations and Reports, 2021 - cdc.gov
These guidelines for the treatment of persons who have or are at risk for sexually transmitted
infections (STIs) were updated by CDC after consultation with professionals knowledgeable …

The penicillin allergy delabeling program: a multicenter whole-of-hospital health services intervention and comparative effectiveness study

KYL Chua, S Vogrin, S Bury, A Douglas… - Clinical infectious …, 2021 - academic.oup.com
Background Penicillin allergies are associated with inferior patient and antimicrobial
stewardship outcomes. We implemented a whole-of-hospital program to assess the efficacy …

[HTML][HTML] Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement

E Alvarez-Cuesta, R Madrigal-Burgaleta… - World Allergy …, 2022 - Elsevier
Drug hypersensitivity reactions (DHRs) to intravenous drugs can be severe and might leave
patients and doctors in a difficult position where an essential treatment or intervention has to …

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

H Breiteneder, Z Diamant, T Eiwegger, WJ Fokkens… - Allergy, 2019 - Wiley Online Library
The specialties of allergy and clinical immunology have entered the era of precision
medicine with the stratification of diseases into distinct disease subsets, specific diagnoses …

Antibiotic allergy in pediatrics

AE Norton, K Konvinse, EJ Phillips, AD Broyles - Pediatrics, 2018 - publications.aap.org
The overlabeling of pediatric antibiotic allergy represents a huge burden in society. Given
that up to 10% of the US population is labeled as penicillin allergic, it can be estimated that …

Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge: a systematic review

L Cooper, J Harbour, J Sneddon… - JAC-Antimicrobial …, 2021 - academic.oup.com
Background Approximately 10% of people have an unverified penicillin allergy, with multiple
personal and public health consequences. Objectives To assess the efficacy and safety of …

Cross-reactivity to cephalosporins and carbapenems in penicillin-allergic patients: two systematic reviews and meta-analyses

M Picard, G Robitaille, F Karam, JM Daigle… - The Journal of Allergy …, 2019 - Elsevier
Background There is no recent systematic review on the risk of cross-reactivity to
cephalosporins and carbapenems in penicillin-allergic patients despite many new studies …