Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists

G Guerriero, R Berni, JA Muñoz-Sanchez, F Apone… - Genes, 2018 - mdpi.com
Plants are sessile organisms and, in order to defend themselves against exogenous (a)
biotic constraints, they synthesize an array of secondary metabolites which have important …

Jasmonates are signals in the biosynthesis of secondary metabolites—Pathways, transcription factors and applied aspects—A brief review

C Wasternack, M Strnad - New biotechnology, 2019 - Elsevier
Jasmonates (JAs) are signals in plant stress responses and development. One of the first
observed and prominent responses to JAs is the induction of biosynthesis of different groups …

Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield

B Liao, X Shen, L Xiang, S Guo, S Chen, Y Meng… - Molecular plant, 2022 - cell.com
Artemisia annua is the major natural source of artemisinin, an anti-malarial medicine
commonly used worldwide. Here, we present chromosome-level haploid maps for two A …

High-level semi-synthetic production of the potent antimalarial artemisinin

CJ Paddon, PJ Westfall, DJ Pitera, K Benjamin… - Nature, 2013 - nature.com
In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths. The
World Health Organization has recommended artemisinin-based combination therapies …

SLAF-seq: An Efficient Method of Large-Scale De Novo SNP Discovery and Genotyping Using High-Throughput Sequencing

X Sun, D Liu, X Zhang, W Li, H Liu, W Hong, C Jiang… - PloS one, 2013 - journals.plos.org
Large-scale genotyping plays an important role in genetic association studies. It has
provided new opportunities for gene discovery, especially when combined with high …

The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis

Q Shen, L Zhang, Z Liao, S Wang, T Yan, PU Shi, M Liu… - Molecular plant, 2018 - cell.com
Artemisia annua, commonly known as sweet wormwood or Qinghao, is a shrub native to
China and has long been used for medicinal purposes. A. annua is now cultivated globally …

A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

P Fuentes, F Zhou, A Erban, D Karcher, J Kopka… - elife, 2016 - elifesciences.org
Artemisinin-based therapies are the only effective treatment for malaria, the most
devastating disease in human history. To meet the growing demand for artemisinin and …

Construction and analysis of high-density linkage map using high-throughput sequencing data

D Liu, C Ma, W Hong, L Huang, M Liu, H Liu, H Zeng… - Plos one, 2014 - journals.plos.org
Linkage maps enable the study of important biological questions. The construction of high-
density linkage maps appears more feasible since the advent of next-generation …

Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects

LW Sumner, Z Lei, BJ Nikolau, K Saito - Natural product reports, 2015 - pubs.rsc.org
Covering: 2000 to 2014 Plant metabolomics has matured and modern plant metabolomics
has accelerated gene discoveries and the elucidation of a variety of plant natural product …

Glandular trichomes: micro‐organs with model status?

R Schuurink, A Tissier - New Phytologist, 2020 - Wiley Online Library
Glandular trichomes are epidermal outgrowths that are the site of biosynthesis and storage
of large quantities of specialized metabolites. Besides their role in the protection of plants …