The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

Hypoxia is a physiological cue that impacts diverse physiological processes, including
energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the …

All cells sense and respond to various mechanical forces in and mechanical properties of
their environment. To respond appropriately, cells must be able to sense the location …

Recent findings about cell fate change induced by physical stimuli have expedited the
discovery of underlying regulatory mechanisms that determine stem cell differentiation …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that mediates
adaptive responses to hypoxia. We demonstrate that lysosomal degradation of the HIF-1α …

The phenotypic expression and function of stem cells are regulated by their integrated
response to variable microenvironmental cues, including growth factors and cytokines …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

The mammalian heart regenerates poorly, and damage commonly leads to heart failure.
Hippo signaling is an evolutionarily conserved kinase cascade that regulates organ size …