G protein-coupled receptors (GPCRs) regulate every aspect of kidney function by mediating
the effects of various endogenous and exogenous substances. A key concept in GPCR …

The translation of in vitro potency of a candidate drug, as determined by traditional
pharmacology metrics (such as EC50/IC50 and KD/Ki values), to in vivo efficacy and safety …

The stabilization of different active conformations of G protein–coupled receptors is thought
to underlie the varying efficacies of biased and balanced agonists. Here, profiling the …

Quantum pharmacology introduces theoretical models to describe the possibility of ultra-
high dilutions to produce biological effects, which may help to explain the placebo effect …

Cancer is a multifaceted, complex disease characterized by unchecked cell growth, genetic
mutations, and dysregulated signalling pathways. These factors eventually cause evasion of …

The octapeptide angiotensin II (Ang II) is a circulating hormone as well as a locally formed
agonist synthesized by the angiotensin-converting enzyme (ACE) of endothelial cells. It …

The varying efficacy of biased and balanced agonists is generally explained by the
stabilization of different active receptor conformations. In this study, systematic profiling of …

Background Tachyphylaxis is the rapid development of drug tolerance following repeated
administration. Objectives To evaluate the United States Food and Drug Administration …

Os receptores de sete domínios de membrana (GPCR) são proteínas que, ao serem
ativadas por hormônios, neurotransmissores ou fármacos, disparam vias de sinalização …