The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

Gregoire, Francine M., Cynthia M. Smas, and Hei Sook Sul. Understanding Adipocyte
Differentiation. Physiol. Rev. 78: 783–809, 1998.—The adipocyte plays a critical role in …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

The activity of TGF-β1 is regulated primarily extracellularly where the secreted latent form
must be modified to expose the active molecule. Here we show that thrombospondin-1 is …

Regulation of development and differentiation by the extracellular matrix Page 1
INTRODUCTION Differentiation is a continuously regulated process and interactions between the …

Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors,
bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic …

Regulation of the activation of latent TGF-β is essential for health as too much or too little
TGF-β activity can have serious, deleterious consequences. The processes that control …

The multifaceted action of thrombospondin-1 (TSP-1) depends on its ability to physically
interact with different ligands, including structural components of the extracellular matrix …

The name myofibroblast was proposed several years ago for fibroblastic cells located within
granulation tissue and exhibiting an important cytoplasmic microfilamentous apparatus [1 …