Arterial stiffening occurs with age and is closely associated with the progression of
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …

Coronary atherosclerosis is the major cause of mortality and disability in developed nations.
A deeper understanding of mechanical properties of coronary arteries and hence their …

Abstract Design strategies for small diameter vascular grafts are converging toward native-
inspired tissue engineered grafts. A new automated technology is presented that combines …

Computational implementation of physical and physiologically realistic constitutive models is
critical for numerical simulation of soft biological tissues in a variety of biomedical …

Among the three layers of the aortic wall, the media is primarily responsible for its
mechanical properties, but the adventitia prevents the aorta from overstretching and …

The load bearing properties of large blood vessels are principally conferred by collagen and
elastin networks and their microstructural organization plays an important role in the …

Collagen plays a key role in the strength of aortic walls, so studying micro-structural changes
during disease development is critical to better understand collagen reorganization. Second …

Background and objective The trabecular meshwork (TM) consists of extracellular matrix
(ECM) with embedded collagen and elastin fibers providing its mechanical support. TM …

The mechanical properties of arterial tissue play a central role in healthy human physiology
and have therefore been extensively studied and modeled in recent decades. These …

Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …