Tendons and ligaments are connective tissues that guide motion, share loads, and transmit
forces in a manner that is unique to each as well as the anatomical site and biomechanical …

Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …

The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of
collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of …

Tendon injuries are often associated with significant dysfunction and disability due to
tendinous tissue's very limited self-repair capacity and propensity for scar formation. Dental …

The structural dynamics of thin-walled parts vary as the material is removed during
machining. This paper presents a new, computationally efficient reduced order dynamic …

Impaired healing leading to the formation of ulcerated wounds is a critical concern in
patients with diabetes. Abnormalities in extracellular matrix (ECM) production and …

Cells integrate mechanical cues to direct fate specification to maintain tissue function and
homeostasis. While disruption of these cues is known to lead to aberrant cell behavior and …

Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain
and lead to complete rupture of the tendon, which often requires surgical repair. Due in part …

Extracellular matrix (ECM) determines the physiological function of all tissues, including
musculoskeletal tissues. In tendon, ECM provides overall tissue architecture, which is …

The physiology of connective tissues like tendons and ligaments is highly dependent upon
the collagens and other such extracellular matrix molecules hierarchically organized within …