Disorders of the cardiac rhythm may occur in both the fetus and neonate. Because of the
immature myocardium, the hemodynamic consequences of either bradyarrhythmias or …

Purpose: Innovative and sustainable sampling strategies for bioanalytical quantification of
drugs and metabolites have gained considerable interest. Scavenging can be stratified as a …

Background: Neonatal hypoxia-ischemia encephalopathy (HIE) is the leading cause of
neonatal death and poor neurodevelopmental outcomes worldwide. Therapeutic …

Chagasic chronic cardiomyopathy (CCC) is the primary clinical manifestation of Chagas
disease (CD), caused by Trypanosoma cruzi. Current therapeutic options for CD are limited …

Challenges in conducting and completing studies of drugs in vulnerable populations, such
as hospitalized children, include weak study designs and lack of sufficient sample sizes to …

The population pharmacokinetics of amiodarone and its active metabolite, N‐
desethylamiodarone (DEA) were investigated in paediatric patients with arrhythmias, mainly …

Amiodarone is a class III antiarrhythmic agent that inhibits adrenergic stimulation by blocking
alpha and beta receptors. It prolongs action potential and refractory period in myocardial …

Objective Determine the pharmacokinetics (PK) and exposure–response of
hydroxychloroquine (HCQ) and desethylhydroxychloroquine (DHCQ) in paediatric SLE …

The use of indomethacin to delay delivery in preterm labor (PTL) is widely accepted;
however, the optimal dosage of indomethacin in pregnancy is unknown. Here, we perform …

Background/Aim: The mitochondrial targeted GS-nitroxide, JP4-039, is an effective total
body irradiation (TBI) mitigator when delivered intravenously (IV) up to 72 h after exposure …