Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

[HTML][HTML] Biomimetic strategies for tendon/ligament-to-bone interface regeneration

T Lei, T Zhang, W Ju, X Chen, BC Heng, W Shen… - Bioactive Materials, 2021 - Elsevier
Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex
structure, composition, cell population and mechanics of the interface. With rapid advances …

Conditioned medium of human bone marrow-derived stem cells promotes tendon-bone healing of the rotator cuff in a rat model

W Chen, Y Sun, X Gu, J Cai, X Liu, X Zhang, J Chen… - Biomaterials, 2021 - Elsevier
Rotator cuff repair is a common surgery in sports medicine. During the surgery, torn tendon
was re-fixed onto the bony surface. The majority of patients gain good results. However, re …

Current trends in the anterior cruciate ligament part 1: biology and biomechanics

V Musahl, EM Nazzal, GA Lucidi… - Knee surgery, sports …, 2022 - Wiley Online Library
A trend within the orthopedic community is rejection of the belief that “one size fits all.”
Freddie Fu, among others, strived to individualize the treatment of anterior cruciate ligament …

Infrapatellar fat pad mesenchymal stromal cell–derived exosomes accelerate tendon-bone healing and intra-articular graft remodeling after anterior cruciate ligament …

J Xu, Z Ye, K Han, T Zheng, T Zhang… - … American journal of …, 2022 - journals.sagepub.com
Background: Exosomes derived from mesenchymal stromal cells (MSCs) reportedly
enhance the healing process. However, no studies have investigated the effect of exosomes …

Identification and distinction of tenocytes and tendon-derived stem cells

Y Li, T Wu, S Liu - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Restoring the normal structure and function of injured tendons is one of the biggest
challenges in orthopedics and sports medicine department. The discovery of tendon-derived …

[HTML][HTML] Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway

XD Wu, L Kang, J Tian, Y Wu, Y Huang, J Liu… - Materials Today Bio, 2022 - Elsevier
Graft healing after anterior cruciate ligament reconstruction (ACLR) involves slow biological
processes, and various types of biological modulations have been explored to promote …

The functions and mechanisms of tendon stem/progenitor cells in tendon healing

J Lu, H Chen, K Lyu, L Jiang, Y Chen… - Stem Cells …, 2023 - Wiley Online Library
Tendon injury is one of the prevalent disorders of the musculoskeletal system in orthopedics
and is characterized by pain and limitation of joint function. Due to the difficulty of …

Engineered cell sheets for the effective delivery of adipose-derived stem cells for tendon-to-bone healing

MJ Shin, IK Shim, DM Kim, JH Choi… - … American journal of …, 2020 - journals.sagepub.com
Background: Efforts are being made to treat rotator cuff tears (RCTs) that exhibit poor
healing and high retear rates. Tendon-to-bone healing using mesenchymal stem cells is …

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

B Walia, AH Huang - Journal of Orthopaedic Research®, 2019 - Wiley Online Library
Tendon and ligament injuries are a leading cause of healthcare visits with significant impact
in terms of economic cost and reduced quality of life. To date, reparative strategies remain …