Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …

The mechanisms that extend lifespan in humans are poorly understood. Here we show that
extended longevity in humans is associated with a distinct transcriptome signature in the …

Paroxysmal kinesigenic dyskinesia is the most common type of paroxysmal movement
disorder and is often misdiagnosed clinically as epilepsy. Using whole-exome sequencing …

The mechanisms generating epileptic neuronal networks following insults such as severe
seizures are unknown. We have previously shown that interfering with the function of the …

Epigenetic processes in the brain involve the transfer of information arising from short-lived
cellular signals and changes in neuronal activity into lasting effects on gene expression. Key …

In the healthy brain, neuronal excitability and synaptic strength are homeostatically
regulated to keep neuronal network activity within physiological boundaries. Epilepsy is …

This article highlights the emerging therapeutic potential of specific epigenetic modulators
as promising antiepileptogenic or disease-modifying agents for curing epilepsy. Currently …

Prevention of epilepsy and its progression remains the most urgent need for epilepsy
research and therapy development. Novel conceptual advances are required to …

The prevalence of epilepsy is estimated 5–10 per 1000 population and around 70% of
patients with epilepsy can be sufficiently controlled by antiepileptic drugs (AEDs) …