The role of regulatory variation in complex traits and disease

FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

Rare and common variants: twenty arguments

G Gibson - Nature Reviews Genetics, 2012 - nature.com
Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

AL Totura, RS Baric - Current opinion in virology, 2012 - Elsevier
SARS-CoV is a pathogenic coronavirus that emerged from a zoonotic reservoir, leading to
global dissemination of the virus. The association SARS-CoV with aberrant cytokine …

Finding the sources of missing heritability in a yeast cross

JS Bloom, IM Ehrenreich, WT Loo, TLV Lite, L Kruglyak - Nature, 2013 - nature.com
For many traits, including susceptibility to common diseases in humans, causal loci
uncovered by genetic-mapping studies explain only a minority of the heritable contribution to …

MAGIC populations in crops: current status and future prospects

BE Huang, KL Verbyla, AP Verbyla… - Theoretical and Applied …, 2015 - Springer
Key message MAGIC populations present novel challenges and opportunities in crops due
to their complex pedigree structure. They offer great potential both for dissecting genomic …

Multi-parent advanced generation inter-cross (MAGIC) populations in rice: progress and potential for genetics research and breeding

N Bandillo, C Raghavan, PA Muyco, MAL Sevilla… - Rice, 2013 - Springer
Background This article describes the development of Multi-parent Advanced Generation
Inter-Cross populations (MAGIC) in rice and discusses potential applications for mapping …

The genome architecture of the Collaborative Cross mouse genetic reference population

Collaborative Cross Consortium - Genetics, 2012 - academic.oup.com
Abstract The Collaborative Cross Consortium reports here on the development of a unique
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …

Genomes of the mouse collaborative cross

A Srivastava, AP Morgan, ML Najarian, VK Sarsani… - Genetics, 2017 - academic.oup.com
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …

Obesity genetics in mouse and human: back and forth, and back again

FT Yazdi, SM Clee, D Meyre - PeerJ, 2015 - peerj.com
Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …