Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The ATP‐binding cassette (ABC) transporters are a superfamily of membrane proteins that
are best known for their ability to transport a wide variety of exogenous and endogenous …

Introduction: The xenobiotic detoxification system, which protects the human body from
external chemicals, comprises drug-metabolizing enzymes and transporters whose …

Despite regular use of drugs for critically ill patients, overall data are limited regarding the
impact of critical illness on pharmacokinetics (PK). Designing safe and effective drug …

Introduction Chronic kidney disease is a common, progressive illness that is becoming a
global public health problem. In patients with kidney dysfunction, the renal excretion of …

Sex-, species-, and chain length-dependent renal elimination is the hallmark of mammalian
elimination of perfluorocarboxylates (PFCAs) and has been extensively studied for almost …

All cells necessarily contain tens, if not hundreds, of carriers for nutrients and intermediary
metabolites, and the human genome codes for more than 1000 carriers of various kinds …

Transporters govern drug movement into and out of tissues, thereby playing an important
role in drug disposition in plasma and to the site of action. The molecular cloning of such …

Kidney plays an important role in the elimination of drugs, especially with low or negligible
hepatic clearance. An analysis of the interrelation of physicochemical properties and the …

Most members of the large ATP-binding cassette (ABC) gene family are transporters
involved in substrate translocation across biological membranes. In eukaryotes, ABC …