The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …

Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies
show that though specific pulmonary diseases and correlative lung-metabolic deviance own …

The lung is ventilated by thousand liters of air per day. Inevitably, the respiratory system
comes into contact with airborne microbial compounds, most of them harmless …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Severe asthma patients with a significant smoking history have airflow obstruction with
reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of …

Background Genome-wide association studies have identified the ORM (yeast)-like protein
isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk …

Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in
cells as part of normal physiology but occur frequently in diseases involving inflammation. In …

Background C/EBP homologous protein (Chop), a marker of endoplasmic reticulum (ER)
stress, exhibits aberrant expression patterns during asthma development. However, its exact …

Bronchial asthma is a heterogeneous disease characterised by chronic airway inflammation.
A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and …