Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …

Autophagy is a cellular stress response mechanism activation of which leads to degradation
of cellular components, including proteins as well as damaged organelles in lysosomes …

Autophagy is a conserved catabolic process involving the degradation and recycling of
damaged biomacromolecules or organelles through lysosomal-dependent pathways and …

Autophagy is an important process of cellular degradation and has been proven to
contribute to tumorigenesis. High-mobility group box 1 (HMGB1) is an abundant nonhistone …

Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying
mechanism remains unclear. In the present study, we examined whether activation of CB2R …

Macroautophagy/autophagy is a catabolic process that is widely found in nature. Over the
past few decades, mounting evidence has indicated that noncoding RNAs, ranging from …

Brain tumors in children and adults are challenging tumors to treat. Malignant primary brain
tumors (MPBTs) such as glioblastoma have very poor outcomes, emphasizing the need to …

Autophagy has a crucial role in many cancers, including brain tumors. Several types of
endogenous molecules (eg microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate …

Trastuzumab, the first targeted antibody against human epidermal growth factor receptor 2
(HER2), has been used to treat gastric cancer patients with HER2 overexpression. However …