The brain is arguably the most complex organ. The branched and extended morphology of
nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their …

How molecules interact governs how they move. Single-molecule tracking (SMT) thus
provides a unique window into the dynamic interactions of biomolecules within live cells …

Nanobodies are single variable domain antibodies isolated from camelids and are rapidly
distinguishing themselves as ideal recognition elements in biosensors due to their …

The spatio-temporal organization of chromatin in the eukaryotic cell nucleus is of vital
importance for transcription, DNA replication and genome maintenance. Each of these …

Understanding how building blocks of life contribute to physiology is greatly aided by protein
identification and cellular localization. The two main labeling approaches developed over …

Probing the architecture, mechanism, and dynamics of genome folding is fundamental to our
understanding of genome function in homeostasis and disease. Most chromosome …

Since the early 1990s, single-molecule detection in solution at room temperature has
enabled direct observation of single biomolecules at work in real time and under …

Our understanding of the organization of the chromatin fiber within the cell nucleus has
made great progress in the last few years. High-resolution techniques based on next …

We develop a predictive theoretical model of the physical mechanisms that govern the
heritability and maintenance of epigenetic modifications. This model focuses on a particular …

Single-particle tracking (SPT) is a powerful technique to unveil molecular behaviors crucial
to the understanding of many biological processes, but it is limited by factors such as probe …