Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a
degenerative disease that affects millions of people world-wide and places a significant …

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

Engineering a pro-regenerative immune response following scaffold implantation is integral
to functional tissue regeneration. The immune response to implanted biomaterials is …

Painful degeneration of soft tissues accounts for high socioeconomic costs. Tissue
engineering aims to provide biomimetics recapitulating native tissues. Biocompatible …

The inflammatory response to chronic injury affects tissue regeneration and has become an
important factor influencing the prognosis of patients. In previous stem cell treatments, it was …

Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs
to be urgently solved. OA affects the cartilage and entire joint tissues, including the …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

Connective tissues within the synovial joints are characterized by their dense extracellular
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …

The purpose of this review is to assess the state-of-the-art fabrication methods, advances in
genome editing, and the use of machine learning to shape the prospective growth in cardiac …

Implanted bone scaffolds often fail to successfully integrate with the host tissue because they
do not elicit a favorable immune reaction. Properties of bone scaffold not only provide …