Micro total analysis systems for cell biology and biochemical assays

ML Kovarik, PC Gach, DM Ornoff, Y Wang… - Analytical …, 2012 - ACS Publications
Novel applications of micro total analysis systems (μTAS) are addressing fundamental
biological questions, creating new biomedical reagents, and developing innovative cell and …

3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip

KH Lee, J Lee, SH Lee - Lab on a Chip, 2015 - pubs.rsc.org
The liver, the largest organ in the human body, is a multi-functional organ with diverse
metabolic activities that plays a critical role in maintaining the body and sustaining life …

Recent developments in multiplexing techniques for immunohistochemistry

AR Dixon, C Bathany, M Tsuei, J White… - Expert review of …, 2015 - Taylor & Francis
Methods to detect immunolabeled molecules at increasingly higher resolutions, even when
present at low levels, are revolutionizing immunohistochemistry (IHC). These technologies …

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

IK Zervantonakis, CR Kothapalli, S Chung, R Sudo… - …, 2011 - pubs.aip.org
Microfluidic devices allow for precise control of the cellular and noncellular
microenvironment at physiologically relevant length-and time-scales. These devices have …

Microfluidics in the “open space” for performing localized chemistry on biological interfaces

GV Kaigala, RD Lovchik… - Angewandte Chemie …, 2012 - Wiley Online Library
Local interactions between (bio) chemicals and biological interfaces play an important role
in fields ranging from surface patterning to cell toxicology. These interactions can be studied …

Advances in diagnostic microfluidics

A Burklund, A Tadimety, Y Nie, N Hao… - Advances in clinical …, 2020 - Elsevier
Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control
and manipulation, enabling rapid and high-throughput sample processing in integrated …

Proteomic-based electrochemical non-invasive biosensor for early breast cancer diagnosis

SD Alharthi, H Kanniyappan, S Prithweeraj… - International Journal of …, 2023 - Elsevier
Breast cancer is the second highest cause of cancer-related mortality in women worldwide
and in the United States, accounting for around 571,000 deaths per year. Early detection of …

Retina-on-a-chip: a microfluidic platform for point access signaling studies

KH Dodson, FD Echevarria, D Li, RM Sappington… - Biomedical …, 2015 - Springer
We report on a microfluidic platform for culture of whole organs or tissue slices with the
capability of point access reagent delivery to probe the transport of signaling events. Whole …

Delineating intra-tumoral heterogeneity and tumor evolution in breast cancer using precision-based approaches

KR Xulu, EE Nweke, TN Augustine - Frontiers in Genetics, 2023 - frontiersin.org
The burden of breast cancer continues to increase worldwide as it remains the most
diagnosed tumor in females and the second leading cause of cancer-related deaths. Breast …

Au-decorated Ti3C2Tx/porous carbon immunoplatform for ECM1 breast cancer biomarker detection with machine learning computation for predictive accuracy

SH Tumrani, RA Soomro, HK Thabet, S Karakuş… - Talanta, 2024 - Elsevier
Electrochemical immunosensors, surpassing conventional diagnostics, exhibit significant
potential for cancer biomarker detection. However, achieving a delicate balance between …