Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …

Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis.
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Integrin affinity regulation, also termed integrin activation, is essential for metazoan life.
Although talin and kindlin binding to the β-integrin cytoplasmic tail is indispensable for …

The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing
support and maintaining normal epithelial architecture. In the last decade, increasing …

Increased ligand binding to cellular integrins (" activation") plays important roles in
processes such as development, cell migration, extracellular matrix assembly, tumor …

Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role
in the innate immune response against invading bacterial and fungal pathogens, while …

Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix
adhesion. Although all integrins can undergo activation (affinity change for ligands), the …

Cells contain several mechanosensing components that transduce mechanical signals into
biochemical cascades. During cell–ECM adhesion, a complex network of molecules …