Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …

Major depressive disorder (MDD) is associated with reduced concentrations of γ-
aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover …

Protein synthesis is a fundamental process in gene expression that depends upon the
abundance and accessibility of the mRNA transcript as well as the activity of many protein …

Learning and memory require activity-induced changes in dendritic translation, but which
mRNAs are involved and how they are regulated are unclear. In this study, to monitor how …

Processing bodies (p-bodies) are a prototypical phase-separated RNA-containing granule.
Their abundance is highly dynamic and has been linked to translation. Yet, the molecular …

Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …

Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates
the elongation stage of protein synthesis by phosphorylating and inhibiting its only known …

Molecular signaling mechanisms underlying Alzheimer's disease (AD) remain unclear.
Maintenance of memory and synaptic plasticity depend on de novo protein synthesis …

Aims: Synaptic deficits are known to underlie the cognitive dysfunction seen in Alzheimer's
disease (AD). Generation of reactive oxygen species (ROS) by β-amyloid has also been …