Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …

Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

Lung cancer has become the leading cause of cancer death in many economically well-
developed countries. Recent molecular biological studies have revealed that overt lung …

The WW domain-containing oxidoreductase (WWOX) spans the second most common
fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in …

Common fragile sites are large chromosomal regions that preferentially exhibit gaps or
breaks after DNA synthesis is partially perturbed. Fragile site instability in cultured cells is …

In 1979, the first chromosome alteration associated with familial cancer was reported. Five
years later, a fragile site was observed in the same chromosome region. The product of the …

Common fragile sites (CFSs) are regions of the genome prone to breakage by replication
inhibitors (extrinsic replication stress). Recently, we and others observed that oncogene …

The FHIT gene at FRA3B is one of the earliest and most frequently altered genes in the
majority of human cancers. It was recently discovered that the FHIT gene is not the most …

Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity,
are among the most common features of human tumours. The short arm of human …