The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …

Ingestion of innocuous antigens, including food proteins, normally results in local and
systemic immune nonresponsiveness in a process termed oral tolerance. Oral tolerance to …

The transcytosis of antigens across the gut epithelium by microfold cells (M cells) is
important for the induction of efficient immune responses to some mucosal antigens in …

Oral tolerance is the state of local and systemic immune unresponsiveness that is induced
by oral administration of innocuous antigen such as food proteins. An analogous but more …

M cells are specialized intestinal epithelial cells that provide the main machinery for
sampling luminal microbes for mucosal immune surveillance. M cells are usually found in …

The gut‐associated lymphoid tissue is the largest immune organ in the body and is the
primary route by which we are exposed to antigens. Tolerance induction is the default …

Multiple mechanisms of tolerance are induced by oral antigen. Low doses favor active
suppression, whereas higher doses favor clonal anergy/deletion. Oral antigen induces T …

Oral tolerance can develop after frequent exposure to food allergens. Upon ingestion, food
is digested into small protein fragments in the gastrointestinal tract. Small food particles are …

Microfold cells (M cells) are specialized epithelial cells situated over Peyer's patches (PP)
and other organized mucosal lymphoid tissues that transport commensal bacteria and other …

New types of protein sources will enter our diet in a near future, reinforcing the need for a
straightforward in vitro (cell‐based) screening model to test and predict the safety of these …