In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …

Breast cancer is one of the leading causes of cancer-related morbidity and mortality among
women worldwide. Phytoestrogens, plant-derived polyphenols that structurally and …

Breast cancer (BC) is the most often diagnosed cancer among females globally and has
become an increasing global health issue over the last decades. Despite the substantial …

Spatholobus suberectus Dunn (SSD) has been extensively employed in Traditional Chinese
Medicine to treat several ailments. SSD and its active compounds are effective therapeutic …

We previously reported that calycosin, a natural phytoestrogen structurally similar to
estrogen, successfully triggered apoptosis of estrogen receptor (ER)-positive breast cancer …

Formononetin is one of the main components of red clover plants, and is considered as a
typical phytoestrogen. This study further investigated that formononetin inactivated …

Background: Formononetin is an O-methylated isoflavone isolated from the root of
Astragalus membranaceus. It has already been reported that formononetin could inhibit cell …

Introduction: The signaling pathways of the insulin-like growth factors (IGF) have been
implicated in the etiology of a number of epithelial neoplasms including prostate, breast …

Human papillomavirus (HPV) integration is the major contributor to cervical cancer (CC)
development by inducing structural variations (SVs) in the human genome. SVs are directly …

Calycosin, the main component extractable from the herb Radix astragali, has been shown
to inhibit cellular proliferation and induce apoptosis in several cancer cell lines, but the …