Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Background An unmet need exists for focal segmental glomerulosclerosis (FSGS) treatment.
In an 8-week, phase 2 trial, sparsentan, a dual endothelin–angiotensin receptor antagonist …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 670 million infections and …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns
of injury on kidney biopsies, but not specific to underlying pathobiology. Consequently, there …

Background Despite renin–angiotensin–aldosterone system blockade and
immunosuppressive treatment, focal segmental glomerulosclerosis (FSGS) often progresses …

In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative
brought a diverse panel of experts in glomerular diseases together to discuss the 2012 …

Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …

Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular injury,
rather than a single disease, that is caused by diverse clinicopathological entities with …