Cells from organisms with renewable tissues can permanently withdraw from the cell cycle
in response to diverse stress, including dysfunctional telomeres, DNA damage, strong …

This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Recent studies suggest that cancer can arise from a cancer stem cell (CSC), a tumor-
initiating cell that has properties similar to those of stem cells. CSCs have been identified in …

Background A hot new topic in medical treatment is the use of mesenchymal stem cells
(MSC) in therapy. The low frequency of this subpopulation of stem cells in bone marrow …

Helicobacter infection is the leading cause of gastric cancer worldwide. Infection with this
ubiquitous bacterium incites a chronic active immune response that persists for the life of the …

Epithelial cancers are believed to originate from transformation of tissue stem cells.
However, bone marrow–derived cells (BMDCs), which are frequently recruited to sites of …

The tumor microenvironment, composed of non‐cancer cells and their stroma, has become
recognized as a major factor influencing the growth of cancer. The microenvironment has …

Human adult stem cells are being evaluated widely for various therapeutic approaches.
Several recent clinical trials have reported their safety, showing them to be highly resistant to …

Emerging evidence suggests that both human stem cells and mature stromal cells can play
an important role in the development and growth of human malignancies. In contrast to …

Although low-density culture provides an efficient method for rapid expansion of human
mesenchymal stem cells (MSCs), MSCs enriched by this method undergo senescence and …