Today's biomanufacturing processes are still operated based on experience, and thus can
hardly cope with increasing bioprocess complexity. Recently, there is a growing interest in …

With omics data being generated at an unprecedented rate, genome-scale modelling has
become pivotal in its organisation and analysis. However, machine learning methods have …

Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …

Eukaryotic cells are used as cell factories to produce and secrete multitudes of recombinant
pharmaceutical proteins, including several of the current top-selling drugs. Due to the …

Host cell proteins (HCPs) are process-related impurities generated during biotherapeutic
protein production. HCPs can be problematic if they pose a significant metabolic demand …

Salivary proteins are essential for maintaining health in the oral cavity and proximal
digestive tract, and they serve as potential diagnostic markers for monitoring human health …

Glycans are fundamental cellular building blocks, involved in many organismal functions.
Advances in glycomics are elucidating the essential roles of glycans. Still, it remains …

Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …

Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …

In-process quality control of biotherapeutics, such as monoclonal antibodies, requires
computationally efficient process models that use readily measured process variables to …