The theory and practice of hyperpolarization in magnetic resonance using parahydrogen

RA Green, RW Adams, SB Duckett, RE Mewis… - Progress in nuclear …, 2012 - Elsevier
NMR spectroscopy is arguably the most powerful and versatile analytical spectroscopic
method available to analyze nuclides which possess a magnetic dipole moment and …

Application of Parahydrogen Induced Polarization Techniques in NMR Spectroscopy and Imaging

SB Duckett, RE Mewis - Accounts of chemical research, 2012 - ACS Publications
Magnetic resonance provides a versatile platform that allows scientists to examine many
different types of phenomena. However, the sensitivity of both NMR spectroscopy and MRI is …

Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer

RW Adams, JA Aguilar, KD Atkinson, MJ Cowley… - Science, 2009 - science.org
The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance
imaging is very low because the detected signal strength depends on the small population …

Sensitivity enhancement in solution NMR: Emerging ideas and new frontiers

JH Lee, Y Okuno, S Cavagnero - Journal of magnetic resonance, 2014 - Elsevier
Modern NMR spectroscopy has reached an unprecedented level of sophistication in the
determination of biomolecular structure and dynamics at atomic resolution in liquids …

NMR Discrimination of d- and l-α-Amino Acids at Submicromolar Concentration via Parahydrogen-Induced Hyperpolarization

L Dreisewerd, RLEG Aspers, MC Feiters… - Journal of the …, 2023 - ACS Publications
Differentiation of enantiomers represents an important research area for pharmaceutical,
chemical, and food industries. However, enantiomer separation is a laborious task that …

Parahydrogen-based NMR methods as a mechanistic probe in inorganic chemistry

SB Duckett, NJ Wood - Coordination Chemistry Reviews, 2008 - Elsevier
The study of reactions by NMR spectroscopy is normally limited by the poor detection limits
offered by the method. An overview is presented of how chemical reactions can be studied …

2D NMR trace analysis by continuous hyperpolarization at high magnetic field

N Eshuis, RLEG Aspers… - Angewandte Chemie …, 2015 - Wiley Online Library
Nuclear magnetic resonance is often the technique of choice in chemical analysis because
of its sensitivity to molecular structure, quantitative character, and straightforward sample …

Probing signal amplification by reversible exchange using an NMR flow system

RE Mewis, KD Atkinson, MJ Cowley… - Magnetic …, 2014 - Wiley Online Library
Hyperpolarization methods are used in NMR to overcome its inherent sensitivity problem.
Herein, the biologically relevant target nicotinamide is polarized by the hyperpolarization …

Para-Hydrogen Induced Polarization without Incorporation of Para-Hydrogen into the Analyte

KD Atkinson, MJ Cowley, SB Duckett… - Inorganic …, 2009 - ACS Publications
The cationic iridium complexes [Ir (COD)(PR3) 2] BF4 (1a-c)(a, R= Ph; b, R= p-tolyl; c, R= p-
C6H4− OMe) react with parahydrogen in the presence of pyridine to give trans, cis, cis-[Ir …

Ligand effects of NHC–iridium catalysts for signal amplification by reversible exchange (SABRE)

BJA van Weerdenburg, S Glöggler, N Eshuis… - Chemical …, 2013 - pubs.rsc.org
SABRE hyperpolarizes substrates by polarization transfer from para-hydrogen in a metal
complex. We have measured the signal enhancement of pyridine and its exchange rate in …