Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions

JC Gaardbo, HJ Hartling, J Gerstoft… - Journal of Immunology …, 2012 - Wiley Online Library
Treatment of HIV‐infected patients with highly active antiretroviral therapy (HAART) usually
results in diminished viral replication, increasing CD4+ cell counts, a reversal of most …

Fatty liver in lipodystrophy: a review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement

SA Polyzos, N Perakakis, CS Mantzoros - Metabolism, 2019 - Elsevier
Lipodystrophy is a group of clinically heterogeneous, inherited or acquired, disorders
characterized by complete or partial absence of subcutaneous adipose tissue that may …

Structure of C lass B GPCRs: New horizons for drug discovery

A Bortolato, AS Doré, K Hollenstein… - British journal of …, 2014 - Wiley Online Library
C lass B GPCRs of the secretin family are important drug targets in many human diseases
including diabetes, neurodegeneration, cardiovascular disease and psychiatric disorders. X …

Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction

B Upadhya, MJ Haykowsky, J Eggebeen… - Current heart failure …, 2015 - Springer
Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart
failure (HF) in older adults. The primary chronic symptom in patients with HFpEF, even when …

[HTML][HTML] Severe malnutrition and metabolic complications of HIV-infected children in the antiretroviral era: clinical care and management in resource-limited settings

PM Musoke, P Fergusson - The American journal of clinical nutrition, 2011 - Elsevier
More than 2 million children globally are living with HIV infection and> 90% of these reside
in sub-Saharan Africa. Severe acute malnutrition (SAM) remains a major problem for HIV …

The safety and efficacy of growth hormone secretagogues

JT Sigalos, AW Pastuszak - Sexual medicine reviews, 2018 - academic.oup.com
Introduction Growth hormone (GH) increases lean body mass, decreases fat mass,
increases exercise tolerance and maximum oxygen uptake, enhances muscle strength, and …

Nutrition and the HIV-associated lipodystrophy syndrome

CR Loonam, A Mullen - Nutrition research reviews, 2012 - cambridge.org
HIV-associated lipodystrophy syndrome (HALS), comprising metabolic and morphological
alterations, is a known side effect of highly active antiretroviral therapy (HAART). Evidence …

Growth hormone secretagogues: history, mechanism of action, and clinical development

J Ishida, M Saitoh, N Ebner, J Springer… - JCSM Rapid …, 2020 - Wiley Online Library
Growth hormone secretagogues (GHSs) are a generic term to describe compounds that
increase growth hormone (GH) release. GHSs include agonists of the growth hormone …

Growth hormone deficiency and human immunodeficiency virus

V Rochira, G Guaraldi - Best Practice & Research Clinical Endocrinology & …, 2017 - Elsevier
Treatment with highly active antiretroviral drugs (HAART) is associated with several
endocrine and metabolic comorbidities. Pituitary growth hormone (GH) secretion seems to …

The metabolic syndrome and HIV infection

V Li Vecchi, P Maggi, M Rizzo… - Current Pharmaceutical …, 2014 - ingentaconnect.com
The metabolic syndrome (MetS), a cluster of risk factors for cardiovascular disease and type
2 diabetes, has become an important public health problem. Considerable differences in the …