Emergent crisis of antibiotic resistance: A silent pandemic threat to 21st century

F Akram, M Imtiaz, I ul Haq - Microbial pathogenesis, 2023 - Elsevier
Antibiotic resistance has become an indispensably alarming menace to the global
community. The primary factors are overuse and abuse of antibiotics, lack of novel …

Molecular Factors and Mechanisms Driving Multidrug Resistance in Uropathogenic Escherichia coli—An Update

M Rozwadowski, D Gawel - Genes, 2022 - mdpi.com
The rapid emergence of multidrug-resistant (MDR) bacteria indisputably constitutes a major
global health problem. Pathogenic Escherichia coli are listed among the most critical group …

A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery

LM Wee, AB Tong, AJ Florez Ariza… - Cell, 2023 - cell.com
In prokaryotes, translation can occur on mRNA that is being transcribed in a process called
coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well …

Emerging non-antibiotic options targeting uropathogenic mechanisms for recurrent uncomplicated urinary tract infection

YC Chen, WC Lee, YC Chuang - International journal of molecular …, 2023 - mdpi.com
Urinary tract infections (UTIs) are the most frequent bacterial infections in the clinical setting.
Even without underlying anatomic or functional abnormalities, more than 40% of women …

Recurrent urinary tract infections: unraveling the complicated environment of uncomplicated rUTIs

J Josephs-Spaulding, TJ Krogh, HC Rettig… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are frequent in humans, affecting the upper and lower urinary
tract. Present diagnosis relies on the positive culture of uropathogenic bacteria from urine …

SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria

EME Dokla, NS Abutaleb, SN Milik, EAEA Kandil… - European Journal of …, 2023 - Elsevier
Antibiotic-resistant bacteria represent a serious threat to modern medicine and human life.
Only a minority of antibacterial agents are active against Gram-negative bacteria. Hence, the …

The role of outer membrane proteins in UPEC antimicrobial resistance: A systematic review

IC Rodrigues, SC Rodrigues, FV Duarte, PM Costa… - Membranes, 2022 - mdpi.com
Uropathogenic Escherichia coli (UPEC) are one of the most common agents of urinary tract
infection. In the last decade, several UPEC strains have acquired antibiotic resistance …

Efflux impacts intracellular accumulation only in actively growing bacterial cells

EE Whittle, HE McNeil, E Trampari, M Webber… - MBio, 2021 - Am Soc Microbiol
For antibiotics with intracellular targets, effective treatment of bacterial infections requires the
drug to accumulate to a high concentration inside cells. Bacteria produce a complex cell …

[HTML][HTML] The influence of efflux pump, outer membrane permeability and β-lactamase production on the resistance profile of multi, extensively and pandrug resistant …

RA Hussein, SH Al-Kubaisy, MTS Al-Ouqaili - Journal of Infection and …, 2024 - Elsevier
Background An important chance of nosocomial acquired infections are caused by the
opportunistic bacterium Klebsiella pneumoniae. Urine, wound, sputum, and blood samples …

Volatile Organic Compounds Produced by Kosakonia cowanii Cp1 Isolated from the Seeds of Capsicum pubescens R & P Possess Antifungal Activity

JL Hernández Flores, YJ Martínez, MÁ Ramos López… - Microorganisms, 2023 - mdpi.com
The Kosakonia cowanii Cp1 strain was isolated from seeds of Capsicum pubescens R. & P.
cultivated in Michoacan, Mexico. Genetic and ecological role analyses were conducted for …