Oxidative stress has long been implicated in cardiovascular disease, but more recently, the
role of reactive oxygen species (ROS) in normal physiological signaling has been …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed
via post-translational modification. However, the mechanism and physiological significance …

The tumour suppressor PTEN is frequently lost in human cancers. In addition to gene
mutations and deletions, recent studies have revealed the importance of post-translational …

Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …

Background USP13 has been reported to be involved in the tumorigenesis of human
cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) …

Chronic obstructive pulmonary disease (COPD) is characterised by irreversible airflow
limitation associated with chronic inflammation. Matrix metalloproteinases (MMPs) are …

The tumor suppressor gene phosphatase and tensin homolog (PTEN) is essential in
inhibiting tumor growth and metastasis. However, the mechanism by which PTEN restricts …

Objective Molecular alterations in endometrial cancer have been shown to be prognostically
significant but have not yet been implemented in the current clinical risk assessment. Few …

Mutations and deletions of the tumour suppressor phosphatase and tensin homologue
deleted on chromosome 10 (PTEN) are frequently involved in the development of cancer …